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Heart and brain defects observed in E8-E10 mousembryososuggestst defective cell migration, and/or reduced mechanical stability or turnover of contact sites.
The videos suggest tantalizing links between the shape and function of defective cell parts, offering insight into how genetic defects contribute to disease.
Therefore the defect in Bgs1 localization to the plasma membrane might be responsible of the defective cell wall in cdc42L160S cells.
Guthrie, B. & Wickner, W. Trigger factor depletion or overproduction causes defective cell division but does not block protein export.
The important exceptions to this rule are people with cystic fibrosis, the genetic disease in which a defective cell protein causes abnormalities in many body fluids.
These results suggested that SERPINB2 could serve as a sensitive marker for predicting toxic responses such as defective cell proliferation or differentiation to various chemicals.
Similar(9)
As a result of defective cell-surface LDL receptors, clearance of LDL from plasma is reduced leading to increased plasma levels of LDL cholesterol and total cholesterol [1].
The majority of illness is among patients with defective cell-mediated immunity.
Children with defective cell-mediated immunity may not develop the characteristic measles rash so infection may go unrecognized [ 18, 20].
This finding could be explained by a possible defective cell-mediated immunity against HPV induced by tobacco [ 37].
Interruptions of these interactions (like Orc1 H4K20me2) that lead to defective cell-cycle progression or cell proliferation may explain the distorted growth in MGS.
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