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The small value of the hyperchromic coefficient indicates that a part of the bases does not take part in hybridization and other ones form defective base pairs distorted with the curvature of the nanotube surface on which hybridized pairs do not reach the conformation with the optimal energy.
In addition, bi-allelic germline MUTYH mutations predispose to adenomatous colorectal polyposis and CRC through defective base excision repair.
Besides, various other mechanisms exist such as defective nucleotide excision repair (NER), defective base excision repair (BER) and defective cell cycle checkpoint controls.
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It noted that the airbags only become defective based on certain factors, such as age.
The European Food Safety Authority (EFSA) evaluated the study as defective based on conceptual and methodological shortcomings by retroactive application of the recommendations of its recent guidance on 90-day feeding studies.
Considering that the number of the initial population is restricted to eight designs, it is more likely that there will be designs considered as being defective based on the initial principles, resulting in its decreased efficiency.
If the patient chooses, inherited defective genes could be replaced with non-defective base-pair sequences, permanently curing any genetic disease and even permitting cancerous cells to be reprogrammed to a healthy state.
A pixel of potentially flawed texture is classified as defective or non-defective based on the Gabor filter response at that pixel.
Cells were also co-transfected with Cdc20 siRNA and mutant plasmids encoding untagged AAA-Bcl-2 (with mutations T69A, S70A and S87A) or HA-tagged S62A-Bcl-xL, both of which are predicted to be phospho-defective based on identified sites of phosphorylation.
The strains most sensitive to Mn2+ were those defective in base excision repair, glutathione synthesis, and superoxide dismutase mutants.
Tumors with certain DNA repair defects that lead to defective HR, based on synthetic lethality, are very sensitive to PARP inhibition.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com