One of the only graceful moments in "Cradle 2 the Grave," a movie that has the flailing momentum of a defective action toy run amok, comes when the camera pulls back to observe Jet Li leaping from a building and dropping from ledge to ledge in a superhuman exhibition of acrobatic nerve.
Symptom-specific effects of defective action monitoring may only be detectable on moderate levels of perceptual load since higher levels may involve confounding attentional disturbances in schizophrenic patients.
However, the conclusion that the perceptual modality which provides data for the defective action monitoring process i.e visual or proprioceptive for passivity experiences, auditory for auditory hallucinations determines the modality of perceptual symptoms is not accepted unequivocally.
These observations support the idea that passivity symptoms are caused by defective action monitoring as suggested by Frith and Blakemore (Frith et al., 2000 a ): Both AMDP -and SAPS- passivity scores were correlated with increased latency in the detection of incongruence between own actions and resulting visual feedback.
It is possible that defective androgen action determined the congenital glaucoma.
However, the underlying molecular mechanisms causing defective BAX action still remain elusive.
Defective insulin action in the skin has been proposed as an important mechanism contributing to wound healing defects in diabetes.
We propose that impaired self-other differentiation in patients with C9ORF72 mutations may index a generic mechanism of defective own-action modeling and representation that may be somewhat analogous to the deficit proposed previously in patients with schizophrenia (6).
Plasma lipid profiling in patients with LD and INSR mutations indicates that the relative enrichment of shorter chain saturated TAG species associated with human IR in previous studies is not purely a secondary consequence of defective insulin action.
At a cellular level, reduced neutrophil chemotaxis, defective fibroblast action, and impaired capacity of other cell populations for migration and proliferation (Jude et al 2002; Jeffcoate et al 2004; Blakytny and Jude 2006) have been found.
