Sentence examples for defective ability from inspiring English sources

A basis for such abnormality has been identified in a defective ability to habituate to repetitive sensorial stimulation.

For example, in Memento the fragmented sequential order of scenes is to put the audience into a similar experience of Leonard's defective ability to create new long-term memories.

The purpose of the fragmented reverse sequencing is to force the audience into a sympathetic experience of Leonard's defective ability to create new long-term memories, where prior events are not recalled, since the audience has yet to see them.

We directly examined whether aging led to a defective ability of recipient splenic DCs to prime and activate antigen specific T cells.

In this paper, we observed that MoDC from HCV chronically infected patients presented a defective ability to stimulate IFNγ secretion by T cells upon LPS maturation.

However, we did not discern that aged splenic DCs exhibited a defective ability to expand and activate antigen specific CD8+ T cells as compared to young DCs.

The majority of the CD4+ T cells that remain in individuals with persistent viremia have defective proliferation ability due to impaired development of IL-2 producing TCM cells [40], PD-1 and CTLA-4 expression [29], [41].

The mutants have missense mutations in residues 247 (Tand240G) and 240 (that240P) that confer high and defective transactivation ability to the mutants, respectively [ 14].

Senescent CD8+ T cells show functional changes and have defective killing abilities due to the loss of perforin and granzyme or defects in granule exocytosis (Appay et al, 2000; Vallejo, 2005).

We suggested that such defective suppression abilities were a possible source of dunce mutant's learning deficits in olfactory [5] and/or visual [6] assays, where ongoing stimulus suppression dynamics may play a role in the normal acquisition or retrieval of memories.

More importantly, senescent T cells have exhibited functional changes, including defective killing abilities and the development of potent negative regulatory functions (Appay et al, 2000; Chen et al, 2009; Cortesini et al, 2001; Montes et al, 2008; Vallejo, 2005; Ye et al, 2012).