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As expected, the Z-line defect was restricted to slow muscles.

The transmission defect was restricted to the spinal cord, as peripheral compound motor action potentials (CMAP) from the sciatic notch to the gastrocnemius muscle did not differ with regard to latency (P = 0.260) (Figure 4G) or amplitude (P = 0.477) (Figure 4H) between controls and mice receiving perforin-competent SCILs.

To determine whether this endocytic defect was restricted to the MR or whether other receptors were also aberrantly expressed, the surface expression of other receptors involved in antigen uptake was evaluated.

This defect was restricted to IL-7 rathan than its receptor (IL-7R) because the expression of the IL-7 receptor α chain (IL-7Rα) was normal, and peripheral blood mononuclear cells responded normally to exogenous IL-7.

Similar(56)

This result shows that these mutants are able to move and that their defect is restricted to high quality food and is not linked to a basic locomotory defect.

Together, the data indicate that linc Brn1b knockout mice exhibit a decrease in proliferation of cortical progenitors in vivo, and that this defect is restricted to a specific subpopulation of progenitors in the SVZ of the developing cortex.

The analysis of the animal model described here indicates that onco-Dbl expression can induce major abnormalities even if such defects are restricted to the lens tissue.

To determine whether the localization defects were restricted to lamins, we examined the localization of Klaroid (46).

In contrast to the bone marrow failure and various tissue defects seen in DBA, TSC defects are restricted to the craniofacial tissues that originate from the neural crest.

Both of these defects are restricted to soft palate development and do not appear to involve the hard palate, which is a common cause of human SMCP.

However, phenotypic analyses of Drosophila ball mutants showed that severe chromatin defects are restricted to the oocyte nucleus (Ivanovska et al., 2005).

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