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After articular surface elevation, the resulting metaphyseal defect was grafted with iliac crest autograft.
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The bony defect were grafted with Bio-Oss® only (group 1, n = 9), Bio-Oss® wetted with rhBMP-2 (group 2, n = 9), Bio-Oss® wetted with rhBMP-2 and 1 mM alendronate (group 3, n = 9) and Bio-Oss® wetted with rhBMP-2 and 10 mM alendronate (group 4, n = 9).
Apicomarginal defects were grafted with Bio-Oss bone mineral and covered with a Bio-Gide membrane.
After creating 5-mm segmental defects in the radii of the rats, defects were grafted using DBM, HA and DBM/HA mixture.
Four millimeter mid-diaphyseal defects were grafted with live autografts or processed allografts and allowed to heal for 6, 9, 12, or 18 weeks.
The defects were grafted with DDM using four different particle sizes and densities: 0.1 mL of 0.25- to 1.0-mm particles (group 1); 0.2 mL of 0.25- to 1.0-mm particles (group 2); 0.1 mL of 1.0- to 2.0-mm particles (group 3); and 0.2 mL of 1.0- to 2.0-mm particles (group 4).
A total of four defects were grafted with DDM of different particle sizes and densities (Fig. 2), as follows: 0.1 mL of 0.25- to 1.0-mm particles (group 1); 0.2 mL of 0.25- to 1.0-mm particles (group 2); 0.1 mL of 1.0- to 2.0-mm particles (group 3); and 0.2 mL of 1.0- to 2.0-mm particles (group 4).
All bony defects were grafted with a 50 50 volume mix of BoneSave (Table 1) and allograft from donor human femoral heads.
In 4 cases associated with a small size component, a central defect in the glenoid surface was grafted with cancellous bone graft from iliac crest.
After the formation of a bilateral parietal bone defect (diameter 8.0 mm), either 4HR-incorporated SFM or conventional SFM was grafted into the defect.
Bio-Oss was grafted to restore the labial dehiscence defect.
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