To uncover specific physiological functions of miRNAs and other regulatory mechanisms acting with miRNAs during development, we performed a genetic enhancer screen for developmental defects that manifested only when miRISC function and another regulatory mechanism were both compromised.
Lrig3 mutant mice, on the other hand, exhibit obvious developmental defects that manifest as abnormal morphogenesis of the inner ear and craniofacial structures [27].
The noninvasive method presented in this paper may be useful for imaging fine vascular details such as microaneurysms and other capillary defects that manifest in retinal diseases, and for studying leukocytes in live human capillaries.
One failure (case #7) was caused by an internal insulation defect that was manifested by oversensing and the loss of the RV coil electrogram.
Eliminating the OCA-S function by another method, i.e. silencing the p38/GAPDH expression, however, exhibited an H2B expression defect that was manifested prior to that of an H4 gene [ 13].
The developmental function that ROL-3 provides is not known, however mutations in rol-3 lead to defects in gross morphology that manifest as a roller (Rol) phenotype (Brenner, 1974).
One of the observations made from the high-volume production test data is that dies that fail due to a systematic failure have a tendency to form certain unique patterns that manifest as defect clusters at the wafer level.
In summary, we report that nBmp2NLStm mice have an immune system defect that is manifest by decreased ability to clear bacteria from the bloodstream and increased mortality after a secondary systemic bacterial infection.
Agents targeting these pathways may have therapeutic benefit in the subset of lupus patients that manifest similar defects in B-cell regulation.
In some cases, especially in the male, infertility is linked to genetic defects in germ cell development that manifest as reduced quantity or quality of sperm (Hull et al. 1985; Reijo Pera et al. 1995; Xu et al. 2001).
These abnormalities often lead to defects in muscle and nerve function that manifest as disordered movement, psychological disturbance, and loss of reflexes.
