Considering the peripheral nerve system, cellular systems are promising therapies to be applied alone or associated to scaffolds, especially, in neurotmesis injuries where the surgical reconstruction is not possible without tension and there is loss of tissue, creating critical defects of the nerve [ 6].
In rats of inbred strains LEW and DA, a 1.5 cm defect of the sciatic nerve was reconstructed by isograft (n = 10) or conduit (n = 10).
It is important to be able to differentiate whether a patient is complaining of decreased vision from an ocular problem such as cataract or from a defect of the optic nerve.
These defects were hypothetically linked to a common cause represented by the initial defect of the phrenic nerve, which is involved in the embryogenesis of both structures.
In this study, the artificial nerve grafts were used to bridge long-distance defects of peripheral nerves in adult sheep.
In previous studies we demonstrated that the artificial nerve grafts consisting of decellularized veins filled with spider silk could be used to bridge long-distance defects of peripheral nerves in adult sheep [ 6].
In conclusion, PFTBA-enriched nerve conduit is capable of enhancing axonal regeneration, which provides a new avenue for achieving better functional recovery in the treatment of nerve defect.
Myasthenia gravis, chronic autoimmune disorder characterized by muscle weakness and chronic fatigue that is caused by a defect in the transmission of nerve impulses from nerve endings to muscles.
In a rat sciatic nerve model, Lin and coworkers created a 5-mm nerve defect as a model of nerve coaptation under tension and repaired the nerve with 10-0 nylon epineural sutures, fibrin glue, or PEG hydrogel [ 69].
Recently, with the development of tissue engineering research, the studies concerning tissue engineered nerve for the repair of nerve defect have been paid great attention by more and more scholars [ 28– 328.
