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This overall change is likely attributed to a defect in the output rather than the processing during tRNA biogenesis, as both pre- and mature tRNAs increase in a similar fashion in the Hmt1 loss-of-function mutants.
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There is general agreement that postprandial hyperglycemia in type 2 diabetic subjects mainly depends on a defect in the endogenous glucose output (EGO) suppression.
Distributive shock can occur in the presence of a normal or even elevated cardiac output and describes a defect in the vascular trafficking of cardiac output between and within the various organ beds, resulting in local tissue dysoxia in the presence of otherwise normal systemic hemodynamics.
This increase is likely attributed to a change in the overall transcriptional output by RNAPIII, as opposed to a defect in the maturation process of tRNAs.
Analysis of cardiac function utilizing echocardiogram revealed no major defect in overall cardiac output (Supplementary Fig S2A) between genotypes, but echo-derived mass and thickness of the left ventricle were consistently diminished in Ccnd1 KI/KI animals (Supplementary Fig S2B) suggesting a potential role for cyclin D1/1b in this tissue type.
I'm interested in the output".
Results are shown in the 'Output window'.
This term was ignored in the output.
Your Trace outputs will be displayed in the Output window.
"That is a defect in the design".
That's just a defect in the mirror".
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