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A life-threatening AE In-patient hospitalisation A disability/incapacity A congenital anomaly/birth defect in the offspring of a subject Other medical events requiring intervention to prevent one of the above outcomes.
SAEs were defined as any medical event resulting in death, any life-threatening event, any event causing disability or requiring hospitalisation or prolongation of hospitalisation, or any congenital anomaly or birth defect in the offspring of a study participant.
An AE is defined as serious (an SAE) if it results in one of the following outcomes A life-threatening AE In-patient hospitalisation A disability/incapacity A congenital anomaly/birth defect in the offspring of a subject Other medical events requiring intervention to prevent one of the above outcomes.
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"They look the same as those produced in vivo [in the living] and now we are going to do further studies on the biochemistry and epigenetics of these cells," Dr Perrard said.Dr Durand said the French team will be using the sperm of rats produced in the bioreactor to test if there are any defects in the offspring before moving to trials on human sperm.
Maternal heroin abuse has been shown to result in teratogenic neurobehavioral defects in the offspring, but the underlying mechanisms remain largely unknown.
Conclusion: An inadequate intake of protein during pregnancy in conjunction with elevated blood phenylalanine levels appear to have an additive effect in the incidence of congenital heart defects in the offspring of women with hyperphenylalaninemia.
The purpose of this study was to evaluate whether maternal febrile illnesses in early pregnancy are associated with increased risk for congenital heart defects in the offspring and whether such risk is mitigated by multivitamin supplement use.
Objective: The purpose of this study was to determine whether nutritional components other than high maternal blood phenylalanine levels (≥10 mg/dL) are associated with congenital heart defects in the offspring of women with hyperphenylalaninemia.
Hyperhomocysteinaemia is an independent risk factor for thrombosis, atherosclerosis and neural tube defects in the offspring of affected women.
First, we checked Tc distal less (Tc dll) and Tc giant (Tc gt), which elicit well quantifiable defects in the offspring of injected pupae [ 32, 36].
Higher water nitrate ingestion was linked with neural tube defects in the offspring of women who used nitrosatable drugs during the peri-conceptional period (Brender et al. 2004).
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