Sentence examples for defect in the generation from inspiring English sources
We can exclude that this defective orientation results from a defect in the generation of planar polarity cues at the clone border since both fz RNAi) (Fig. 4B,B') and Vang mutant SOPs (Fig. 4D,D') appear to orient their polarity axis relative to the border of the Vang and fz RNAi) clones, respectively.
X-linked agammaglobulinaemia (XLA) is a genetic disorder characterised by a defect in the generation of mature B cells, lack of antibodies production, and susceptibility to recurrent bacterial infections.
A deficiency of these genes results in a defect in the generation of secondary lymphoid structures (Tachibana et al., 2011).
As shown in Figure 1B, while reduced number of CD8+IFNγ+ T cells was observed in IL-15 deficient mice, IL-7 depleted WT mice did not exhibit a defect in the generation of this population.
Whether this is due to a defect in the generation of endothelial progenitors or to an inability of these cells to be released into the circulation is still unknown.
The second hypothesis, based on the overall malformation of the caudal body, postulates a primary defect in the generation of the mesoderm.
In order to define the role of antibodies, we used several mouse strains with individual defects in the generation or functioning of antibodies.
In contrast, when Fyn levels were reduced, thus augmenting γδTCR signal strength, we observed defects in the generation of both IL-17- and IFNγ-producing effectors.
We also performed competitive mixed bone marrow chimeras, and under these conditions Egr-2-/ thymocytes have very profound defects in the generation of iNKT cells (data not shown).
For instance, some defects in the generation and function of DA neurons are obviously part of the Parkinson's disease phenotype but have also been reported in Alzheimer's disease.
