Sentence examples for defect in the establishment from inspiring English sources
Although there was no obvious defect in the establishment of cell polarity to account for the abnormal phenotype observed in N1-KD and N4-KD cell cysts in these experiments, this does not rule out a more subtle deficit in the precise timing of TJ or polarity formation which may impair the development of proper epithelial architecture in this 3D system.
This result suggested that disruption of germ cells migration results in defects in the establishment of the initial (neonatal) SSC niche, eventually leading to impairment of SSC function.
This study raises the possibility that defects in the establishment of brain lateralization could indeed be causative of cognitive or other symptoms of brain dysfunction.
The authors cleanly demonstrate a Yrt independent role and then show that foscrbY10A show defects in the establishment of the actomyosin apparatus cells in a situation where components of the Zonula Adherens are disturb or missing.
The authors cleanly demonstrate a Yrt independent role and then show that foscrb Y10A show defects in the establishment of the actomyosin apparatus cells in a situation where components of the Zonula Adherens are disturb or missing.
While it is believed that defects in the establishment and maintenance of functional neuronal networks due to synaptic/spine dysfunction underlie the clinical symptomatology of autism, the molecular mechanisms causing these defects remain unknown.
Analogous to our previous findings in the adult mouse forebrain, we now find that although Id2 is highly expressed in the developing midbrain there are no obvious defects in the establishment of mDA progenitors.
Despite the expected absence of GFP fluorescence at this stage, most of the affected embryos (78%) displayed profound defects in the establishment of the DV polarity, as shown by the absence of the larval arms and aboral vertex, and the reduced number of pigment cells.
