In the datasets, there are defects in the data, such as a postcode missing from the reviewed business, or some geolocation is inaccurate, or the name of a business may have different spelling (using "&" for "and" or "65" for "sixty-five", and so on).
3) At regular intervals the administrator of the EpiArk searches all database tables for obvious defects in the data, such as impossible date intervals, impossible birth dates or duplicates.
This phenotype defect is characteristic for mutants that cannot respond to a chemical gradient generated upon nutrient consumption and was not due to a defect in the growth rate (data not shown).
However, these modifications of the modeling strategy do not compensate for the defects in the modeling data used for training the prediction methods.
Our space deformation technique based on moving least squares approximation improves upon existing approaches in crucial aspects: It offers the same level of modeling flexibility as surface-based deformations, but it is independent of the underlying geometry representation and therefore highly robust against defects in the input data.
However, defects in the GRN data are very unlikely to undermine our conclusions, for various reasons.
We provide diagnostic plots and a simple logistic regression based test statistic to detect these intensity related defects in the processed data.
Though the Δppk2 mutant did not show a defect in adherence (data not shown), the mutant exhibited a significant (P≤0.05) dose-dependent defect in invasion (Figure 7A).
Interestingly, we observed a slight but not significant decrease in PAS-positive cells in the airways of ICOS+/− mice compared to ICOS+/+ mice suggesting that decreased ICOS expression induces a defect in the cellular immune response (data not shown).
Our data do not definitively determine the cause of the respiratory defect in the absence of MICOS, Our data do not definitively determine the cause of the respiratory defect in the absence of MICOS, beyond noting that there is a subtle defect in complex IV activity.
