These results suggest that the differences between transgenic (WTTg and KOTg) and non-transgenic (WT and KO) mice were due to locomotion defects rather than defects in anxiety or exploratory behavior.
For many patients, there is a psychological impact of retaining the maxillectomy defect and high anxiety related to the insertion and removal of the prosthesis as well as concerns relating to the handicap they would experience to speech, and eating should their prosthesis fracture or fail in some way.
Like in cretinism, these TRα1+m mice present a plethora of brain defects, e.g. high anxiety, locomotor dysfunction and defects in the control of autonomic functions [ 7– 9].
Termination of pregnancy is not a legal or cultural option in many African countries, and hence exposure of pregnant women to medications that may increase the risk of birth defects could cause patient anxiety or illegal induced termination of a pregnancy.
Shank3 wild-type, heterozygous and knockout mice from the three genetic backgrounds were evaluated in a battery of tests that had been designed to assess the main features of PMS, including assays for neurodevelopment changes, sensory-motor defects, hyperactivity, emotionality and anxiety, as well as behaviors relevant to ASD.
Interestingly, Bdr mice display a range of behavioural defects including some aspects of anxiety and apathy but also a robust reduction in PPI response.
Scn8a Clth mice did not show any significant differences in any parameters tested in the open-field test, indicating no observed anxiety or locomotion defects compared with wild-type mice (Fig. 5b).
In the mouse FXS model, minocycline promoted the maturation of hippocampal dendritic spines towards normal morphology, both in vitro and in vivo, and repressed anxiety and memory defects in an elevated plus-maze test (Bilousova et al., 2009).
A microdeletion at the chromosomal location 7q11.23 encoding TFII-I and the related family of transcription factors may result in the onset of Williams Beuren syndrome, an autosomal dominant genetic disorder characterised by a unique cognitive profile, diabetes, hypertension, anxiety, and craniofacial defects.
These defects suggest a possible increase in either anxiety or phobia in Rac1N mice.
