Sentence examples for defeat model from inspiring English sources
A major weakness of the social defeat model has been an inability to test hypotheses in females.
Although the social defeat model robustly induces behavioral responses related to mood disorders, its use has been constrained almost entirely to males.
The social defeat model induces a constellation of long lasting behavioral responses in many species that mimic aspects of psychiatric disorders [4].
The social defeat model induces behavioral responses in rodents (e.g. reduced social interaction) that are similar to behavioral patterns associated with mood disorders.
These aggressive behaviors can be observed during resident-intruder tests in a laboratory setting, thus allowing for the use of the social defeat model in an ethologically relevant context.
At the same time, social defeat model may also relate to panic disorder, social phobia, or PTSD [ 52, 119].
A number of studies have shown that animals with subdominant behavioural characteristics will most frequently exhibit low sucrose preference and anhedonia in similar social defeat models [ 14, 21, 62, 96- 99].
In this "multiple-PDE1C [threshold = 1] + positive-feedback loop defeated" model, the resultant depolarization signals were not greatly elongated (longevity = 13 17; Figure 6H), and the longevity was similar to that of the "single-PDE1C [threshold = 1]" model.
The social defeat stress model has been proposed as a model for depression-like behaviour or for behavioural disturbances associated with post-traumatic stress disorder, while it is furthermore particularly useful for studying the neural basis and the molecular and cellular mechanisms underlying differential vulnerability or sustainability to the effects of chronic social defeat stress.
In April 1945, with the Third Reich's defeat imminent, Model committed suicide rather than be captured.
Tsankova et al showed that HDAC inhibition is an essential step in the behavioral effects of imipramine in the social defeat depression model.
