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In addition to information about >2,000 exogenous factors (morphological, physiological, clinical), LifeLines-DEEP participants have been deeply profiled for multiple "omics" data layers.
For example, the LifeLines-DEEP cohort, a subset of 1,500 individuals from the LIfeLines cohort, is deeply profiled for various "omics" data on the genome, epigenome, transcriptome, proteome, metabolome and gut microbiome (Tigchelaar et al., 2015).
Finally, for the specific case of the NCI-60 cancer cell line dataset, since it has been deeply profiled for many types of research (drug response, chromosomal aberrations, mutational status, etc).
Findings based on analyzing a small number of deeply profiled DNA methylomes (i.e., a discovery panel) can then be validated using array-based approaches, which can be applied to a much bigger number of samples (i.e., a validation panel).
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Lind et al. use the Pseudomonas fluorescens unshaken microcosm experimental evolution system to deeply profile different mutations that can give rise to the wrinkly spreader phenotype.
Here we took a different strategy, which is complementary to that of TCGA, to deeply profile complete DNA methylomes of a small number of tumor specimens using newly developed sequencing-based epigenomics technology [ 19, 20].
Calvin Tompkins's "Living Well Is the Best Revenge" is a deeply revealing profile of Gerald and Sara Murphy, who inspired F. Scott Fitzgerald's "Tender is the Night," a book that I've been obsessed with since adolescence.
A deeply reported Profile of the director Mike Nichols, whose situational brilliance seems born of a corrosive desire for control and, even more, for revenge (on his parents, on his doubters, on fate).
Among these areas are vast regions of Regolith-Dominated Terrains (RTD) with basement rock suites buried under thick transported cover and/or deeply weathered profiles.
Likewise, a molten chocolate cake made with bitter-tinged Noir Guanaja takes on a deeply aromatic profile.
I was deeply disturbed to read news reports about a prospective student who felt profiled on or near campus because of his race.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com