More in general, the MAPK and the PIK3CA signalling pathways both have a key role in cell proliferation and survival; their oncogenic activation deeply contributes to pathogenesis of different solid tumours, including HCC.
Numerous clinical studies indicated that overexpression of LAMC2 was positively correlated with invasiveness and poor survival in several types of cancer (Guess and Quaranta, 2009), suggesting that LAMC2 functions as an oncogene and deeply contributes to cancer metastasis.
Filling in the gaps left by the pope at Regensburg, he mentions the Islamic thinkers "who deeply contributed to both Europe and the west at large, nurturing and enriching them with their critical reflections".
It would also give today's Muslims a way of reconciling themselves with the immense creativity of the European Muslim thinkers of the past, who 10 centuries ago were confidently accepting their European identity (not obsessed by the on-going sterile debates on "integration") and who deeply contributed to, nourished and enriched with their critical reflection both Europe and the west as a whole.
Words are important and their misuse has deeply contributed to the downward spiral that this nation has found itself in for the past several years.
Rather, studies documenting a practice 'more widely' contribute one type of evidence, while those documenting a practice 'more deeply' contribute another type of evidence.
Understanding the role of genetic basis in oyster resistance or susceptibility to infection should deeply contribute to identify the causes of mortalities and the traits that characterize enhanced survival capacities in oyster populations.
It is a well-documented phenomenon that the value of S 0 is always smaller than the H-R parameter measured between higher order satellite peaks [21] due to the fact that whilst all recombining excitons contribute to the zero order peak, only those that are deeply confined contribute meaningfully to the higher order satellites.
Prior to installation the flow jet was relatively thin, impacting the tailrace as a coherent stream that plunged deeply, possibly contributing to total dissolved gas production.
The British government's claim that Saudi Arabia's bombing campaign in Yemen has not breached international humanitarian law is "deeply disappointing" and contributes to an "anything goes" attitude from the opposing sides in the conflict, the international development select committee has said.
In fact, I deeply believe travel contributes, often granularly, but ultimately measurably, to the solution, or at least the evolution of consciousness.
