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"Russian oligarchs have spread a lot of money around Washington over the last decade, but we're not stupid here," he added, noting that Mr. Khodorkovsky's qualities helped generate "a much deeper response than when other Russian businessmen have been hounded".
Multiple trials are currently looking into daratumumab in transplant-ineligible patients with recently released updates, suggesting that the addition of daratumumab allows deeper response, increased PFS, and improved MRD negativity107.
The extent of improved PFS in the transplant arm in both EMN02/HO95 and IFM2009 trials, likely attributed to a deeper response through increased CR and MRD rates, suggest that given more observational time, we could possibly find an improvement in OS as was the case for lenalidomide maintenance.
Lenalidomide significantly improved PFS in all subgroups of patients regardless of age, myeloma severity and staging, and induction regimen (52.8 versus 23.5 months), even though patients who had received lenalidomide in induction, or had achieved a deeper response post-transplant, were more likely to benefit from lenalidomide89.
However, what will shape our deeper response to Ebola?
Meanwhile, specificity in marketing tends to provoke a deeper response.
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Ixazomib also allowed for deeper responses to be achieved92.
Another study demonstrated similar results with deeper responses on melphalan 280 mg/m2 without translating into improved survival76.
But if you are lucky, and you are graced, and the audience is in a particular salutary condition, then these deeper responses will be produced".
Furthermore, although the general practice is to use 3 4 cycles of VTD before transplant, the use of 6 cycles of VTD was associated with deeper responses.
In the past, deeper responses were rarely seen in these patient categories due to inferior therapies and lack of MRD assays.
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