Sentence examples for deeper binding from inspiring English sources

However, water-mediated hydrogen bonds and a unique cation-π sandwich stacking allow 447-52D to be broadly reactive with V3 containing both the GPGR and GPGQ crown motifs, while the deeper binding pocket and a buried Glu in the binding site of 537-10D litst its reactivity to only V3 containing the GPGR motif.

The more hydrophobic character of the human helix V sequence may create a deeper binding site or reposition helix V to favor binding interactions for the hydrophobic rings.

We suggest that the extended EC2 stretch in combination with a deeper binding mode in drd1 is the reason for the larger average size of D1 agonists relative to D2 agonists.

The optimized positions of features, relative to the new set of structure-based excluded volumes in the D1 pharmacophore model, are shifted downward, corresponding to a deeper binding mode in the receptor compared with the corresponding D2 model.

In our drd1 receptor model there is a hydrogen bond between Ser1073.36 and the backbone carbonyl in Asp1033.32, whereas Cys1183.36 is rotated into the drd2 binding pocket and prevents the deeper binding mode.

Notably, quercetin was found to bind inside a rather deep binding pocket in both COX I and II, which is immediately next to hematin.

When the L protomer transitions to the T state, drugs translocate to a binding pocket deeper in the protein; low molecular-mass drugs, however, can apparently bind directly to the deep binding pocket in the T protomer without binding to the access pocket first (Nakashima et al., 2011).

Protein protein interactions have been a challenging class of targets for antagonism with small molecules, because interfacial surfaces are usually large, dynamic, and lack deep binding pockets into which a small molecule could bind and efficiently occlude the interaction.

The side chain of H3K27me3 inserts into a deep binding pocket within the active site cleft (Fig. 2d).

So Turkish rural cinema is less bound up with notions of manifest destiny and the subjugation of nature, and is more a place where a deep, binding nostalgia wells up from the rocks.

The trimethyllysine docks into the deep binding pocket with the three methyl groups anchored by an extensive CH O hydrogen-bonding network (Fig. 3c), which is essential for fixing the conformation of the head group of the bound trimethyllysine.