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The radiation beam can also come from multiple directions, each beam being focused on the deep tumour, delivering a smaller dose to surrounding organs and tissues.
The main role of imaging consists in precisely depicting deep tumour spread, as well as detecting lymph node and distant metastases.
Appropriate assessment of superficial and deep tumour spread, regional lymphadenopathy and distant metastases is essential for staging and therapeutic planning.
Coexpression of MMP-7 and MMP-9 was significantly correlated with deep tumour invasion in MM and SM (P=0.008), and positive nodal metastasis (P=0.008).
Moreover, expression at the invasive front was significantly correlated with deep tumour invasion (P=0.025), positive lymphatic permeation (P=0.026) and positive nodal metastasis (P=0.017).
Besides, there were more patients with old age (P=0.002) and deep tumour invasion (T3 and T4, P=0.001) in the validation set.
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Like x-rays, protons can penetrate tissue to reach deep tumours.
The simulation code MCNP-4C is used to realize an accurate study of the epithermal column in view of the treatment of deep tumours.
All available deep tumour-adjacent margins were tested.
Briefly after tumour resection, the surgeon excised mucosal and deep tumour-adjacent margins from the tissues remaining at the edge of the defect for molecular examination.
When the base of the resection was in continuity with the neck dissection and there were no true deep tumour-adjacent margins, the samples analysed were excised from the lateral aspects of the defect.
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