The paradoxical role of Sall1 in early versus late PCs is mediated by changes in the properties of RGCs versus IPCs and occurs as PCs transition from producing neurons with a deep layer fate to those with a superficial layer fate.
When crude cell contacts were restored by pelleting E29 cells together, most transplanted neurons cells became specified to their normal deep layer fates.
Progenitors transplanted later in the cell cycle, however, produce daughters that are committed to their normal, deep-layer fates.
Therefore, between E11.5 and E14.5, cells are selectively committed to a deep cortical layer fate at the expense of a more superficial cortical layer fate in Sall1 −/− animals compared with controls.
"The Sound of Things Falling" may be a page turner, but it's also a deep meditation on fate and death.
Just as Arab nationalism still runs run deep, with the fate of Palestine its axis, so does Turkish nationalism, which includes a sense that the country deserves a role in the region, and beyond that at least echoes of its Ottoman age.
The notion that two people could be in the same place at the same time, two people who would later become important to each other, has always intrigued me, a kind of serendipitous coincidence that has underscored my deep belief in fate.
We present the story behind the life of a CME, from its magnetic field origins in the solar corona and photosphere to its eventual fate deep in the heliosphere.
The troubles go much deeper than the fate of one threadbare tennis court.
Eyes widening behind his glasses, he digs himself irretrievably deep into the fates of the other characters, and lets go of his own.
