First, we show that neurally adjusted non-invasive ventilation synchronizes assist to inspiratory effort in patients with COPD, whereas dedicated NIV ventilator or ICU ventilator pressure support modes do not ensure acceptable patient-ventilator interaction in individual patients.
Single-circuit home ventilators and/or dedicated NIV ventilators equipped with a turbine or piston differ from double-circuit ICU ventilators, which are pneumatic and supplied with high-pressure sources of gas.
But it is known, as was recently shown [ 14], that the asynchrony index is significantly lower with a dedicated NIV ventilator than with ICU ventilators even when the latter are used with their NIV algorithm.
In bench-test comparisons, including the ventilator used in our study, PSV delivered by dedicated NIV ventilators allowed better patient-ventilator interaction than ICU ventilators with NIV algorithms [ 10, 22].
For the above-stated reasons, the aim of the present study was to evaluate patient-ventilator interaction, using an automated analysis, in COPD patients with NIV-PSV delivered by a dedicated NIV ventilator, and NIV-PSV and NIV-NAVA delivered by an ICU ventilator.
Apart from the use of a dedicated NIV ventilator or specific modes of ventilation like NAVA, the clinicians should be aware that the choice of interface, the humidification system and the appropriate sedation are key factors in improving patient ventilator synchrony.
Twelve COPD patients underwent three 30-minute trials: 1) PSV with dedicated NIV ventilator (NIV-PSVVision), 2) PSV with intensive care unit (ICU) ventilator (NIV-PSVServo-I), and 3) with NIV-NAVA.
In addition, no study has used the EAdi signal to evaluate patient-ventilator interaction with dedicated NIV ventilators.
Our goal was to determine whether it could also induce ultra-fast and whole-body cooling in large animals using a specifically dedicated liquid ventilator.
