Exact(10)
The length of vasoactive treatment has not been evaluated in dedicated trials.
The data measured on dedicated trials was combined with existing standards to make the key step of generating a set of performance criteria.
These histological subtypes should be the focus of dedicated trials.
The exact role of those mechanisms, such as NO-mediated vasodilation in case of nebivolol [ 1, 69], would have to be examined in dedicated trials [ 64].
Such subgroup definitions can be used for predefined subgroup analysis or dedicated trials, or for equal baseline measurement of these subgroup factors in trials to facilitate future meta-analyses, as well as initiatives to combine IPD from several randomised controlled trials, all in order to generate appropriate recommendations for the effective treatment of various subgroups.
Dedicated trials failed to find a significant reduction in CVD outcomes in a diabetic population treated with fenofibrates, [ 26] while meta-analyses conducted upon pre-specified subgroups have confirmed the clinical benefits of fibrates on major CVD events [ 27, 28].
Similar(50)
The randomisation process will be performed by dedicated trial software IHD CLINICAL.
The factor Xa inhibitor fondaparinux has not been prospectively assessed in patients with cancer in a dedicated trial.
Though the Tanzanian respondents did not express themselves as trial citizens, their usual experience of malaria management was certainly enhanced by the specialised, dedicated trial team.
A recent meta-analysis showed that cancer trials were associated with successful recruitment; other factors included having a dedicated trial manager, being a drug trial and testing an intervention only available in a trial setting [ 20].
All sites now have dedicated clinical trials units and trained clinical research staff and are equipped to conduct trials to international (ICH-GCP) standards.
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