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LpxA catalyzes the first step in lipid A synthesis and uses the same substrate, UDP-N-acetyl-D-glucosamine, as is used in the first dedicated step of peptidoglycan biosynthesis [58].
These homologous enzymes are conserved in all carotenogenic taxa and together represent the first dedicated step in carotenoid biosynthesis, making them highly informative to determine the overall phylogenetic topology of carotenoid biosynthesis.
The first dedicated step in lutein biosynthesis is the ε-cyclization of lycopene by LCY-e.
The gene 9-cis-epoxycarotenoid dioxygenase (NCED) catalyzes the first dedicated step and is the key enzyme in ABA biosynthesis [ 114].
The first dedicated step in the biosynthesis of carotenoids is the synthesis of phytoene, a colorless compound which is desaturated and isomerized into all-trans lycopene.
The LOX2 protein catalyzes the first dedicated step in jasmonic acid (JA) biosynthesis and is activated by the transcription factor TCP4 in leaves [ 55].
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