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Thus, none of these tests demonstrated any "neurologic impairment" or "decrements in brain function".
The present data provide evidence in a rodent model that modest degrees of thyroid hormone reduction induced by perchlorate result in persistent decrements in brain function.
Also, we do not agree that their data (Gilbert and Sui 2008) "provide evidence in a rodent model that modest degrees of thyroid hormone reduction induced by perchlorate result in persistent decrements in brain function".
Interpretation of the reported electrophysiologic anomalies in the hippocampus as "neurologic impairment" or "decrements in brain function" by Gilbert and Sui (2008) was not supported by the results of behavioral testing.
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In summary, there are a number of significant decrements in brain polyunsaturated fatty acids and PlsEtns in AD.
In rats, the accumulation of these proteins causes pronounced decrements in brain metabolism allowing the rat more time to seek out food before it collapses from starvation.
However, as observed with PlsEtns, it appears there are decrements in brain choline plasmalogens (PlsChs; Figure 1) [ 28] but not in phosphatidylcholines [ 10].
One of the established actions of ceramides is the activation of brain plasmalogen-selective PLA2 [ 50], thereby potentially contributing to the decrements in brain plasmalogens in AD (see the 'Choline glycerophospholipids' section).
Temporal patterns of longitudinal change in aging brain function.
Brain Function in Old Age.
Researchers Have Restored Basic Brain Function in Dead Pigs.
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