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For females, senescence has profound effects on fitness by decreasing viability and fertility as well as those of her offspring.
To be more specific, the cytotoxicity investigations show that exposure to mounting concentrations of anionic MNPs, from 0.15 to 15 mM of iron, results in a dose-dependent decreasing viability and capacity of PC12 cells to spread neurites in return for nerve growth factor [24].
Trends in neuronal viability conformed with predictions of existing theoretical models of cell freezing, with reduced survival for rapid cooling rates or high plunge temperatures (attributable to intracellular ice formation), and decreasing viability with increasing profile duration (consistent with the known effects of cell dehydration at suboptimal cooling rates).
The cells were less sensitive to cisplatin, with the highest tested dose (400 ng/mL) decreasing viability by approximately 40%.
In addition to decreasing viability, ethanol exposure during development significantly slowed the rate of egg-to-adult development (Fig. 1B).
The results indicated that cooperative inhibition of DAF and MCP genes resulted in dramatically decreasing viability of ME180 cells.
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Exposure to Me2SO at room temperature decreases viability to ∼90%.
Surfactin was found to decrease viability of both breast cancer cell lines studied.
ZnO induces oxidative stress, decreases viability, and increases cell death in Caco-2 cells.
Reactive oxygen species (ROS) are one of the main causes for decreased viability in cryopreserved sperm.
Higher duty cycle imparts detrimental effect on bacterial cell and decreases viability of cells.
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