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5-HT is though to inhibit photic phase shifts by inhibiting the release of glutamate from retinal terminals, as well as by decreasing the responsiveness of retinorecipient cells in the SCN.
DHA can decrease the release of AA from membrane phospholipids by decreasing phospholipase A2 activity [47], and decreasing the responsiveness of toll-like receptor-4 to LPS, thereby suppressing nuclear factor-kappaB activation and subsequent inflammatory gene transcription [48].
It has been suggested that collagen induces a quiescent state by decreasing the responsiveness to different growth factors [ 26, 27].
Dysregulation of this feedback system may play a role in the defects associated with autism spectrum disorders, with loss or reduction in functional MeCP2 decreasing the responsiveness of EGR family members and other IEGs to stimuli which induce the maturation of neuronal networks in typical cortical development.
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With regard to the likely cause of the impaired hormonal responses, chronic exposure to stress could decrease the responsiveness of hypothalamic pituitary adrenal (HPA) axis [1, 4, 7 12].
Quirk, G.J., Likhtik, E., Pelletier, J.G. & Pare, D. Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons.
The adenosine A1receptor antagonist 8-PT decreased the responsiveness of adenosine-induced inhibition of atrial muscle.
The γ-ray radiation-treatment slightly decreased the responsiveness against cyclohexane vapor, because the γ-ray radiation-treatment induced the crosslinking of PE.
We conclude that inhibition of meal-stimulated pancreatic secretion by peptide YY can be explained by its ability to decrease the responsiveness of the pancreas to endogenous secretogogues.
The proportional-integral design will avoid the steady-state error, but it will decrease the responsiveness by almost 1° of magnitude.
Hence, a problem with institutional reforms aimed at increasing the representation of historically disadvantaged groups is that such reforms can and often do decrease the responsiveness of representatives.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com