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Nanomedicine-based combination anticancer therapy can synergistically improve antitumor outcomes through multiple-target therapy, decreasing the dose of each therapeutic agent and reducing side effects.
Decreasing the dose of Cas-Br-E murine leukemia virus when priming neonatal mice results in adult-like, Type 1 protective responses, but the resulting memory cell populations are smaller than after adult priming.
Since we could not find significant differences between abilities of G3-28BBz and G3-28z-41BBL tumorppress tumor growth and to prolong mice survival, a ''stress test'' was run by decreasing the dose of GPC3 CAR-T cells by 10-fold to 1 × 106 cells/mouse.
At 12 months, for chronic patients only, improvements in preventive medication use were noted in 74% (58/78) with 18 stopping all, 19 stopping some and/or decreasing the dose of others, 20 remaining off all, and 1 experiencing a clinical improvement (per clinical judgment) in preventive medication use at 12 months versus baseline.
Thermodilution calibration was performed before and after decreasing the dose of NE.
The rest of the side effects reverted by decreasing the dose of D-PCA.
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Decreasing the doses of general anaesthetics allows more stable cardiopulmonary function during anaesthesia and the development of less side effects.
Recurrent psychiatric symptoms induced by decreasing the doses of antipsychotics are sometimes called "dopamine supersensitivity psychosis" [ 12].
Decreasing the doses of general anaesthetics and other drugs may allow more stable cardiopulmonary function during anaesthesia and the development of less side effects [ 3].
When decreasing the doses of drugs with potent anticholinergic actions, anticholinergic withdrawal symptoms such as insomnia, anxiety and restlessness may occur.
To date, despite the ready availability of rhBMP-2 for clinical use, there is no optimal DDS that can decrease the dose of rhBMP-2 and keep a more sustained release pattern and be effective for bone regeneration21.
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CEO of Professional Science Editing for Scientists @ prosciediting.com