Xu et al. [ 57] proposed that leucine stimulates S6K1 phosphorylation via the mTOR pathway, partly by serving as a mitochondrial fuel through oxidative carboxylation and partly by mediating the allosteric activation of glutamate dehydrogenase, thereby decreasing the activity of AMP-activated protein kinase (AMPK).
Denosumab is a humanized monoclonal antibody and antiresorptive agent that works by decreasing the activity of the receptor activator of nuclear factor kappa B ligand.
Suppression of RASGRP2 may be attenuating the RAS signalling pathway and hence lymphocyte activation (i.e. promoting homeostasis) by directly decreasing the activity of RAS or by activating RAP1 which in turn inhibits RAS.
Caloric restriction and exercise are helpful in decreasing the activity of important oncogenes and activation of silenced tumor suppressors, and may have a positive impact, not only on aging, but also on prevention of cancer.
Increasing mechanical load leads to increase in bone mass by stimulating bone formation and inhibiting bone resorption through the activation of osteoblast cells and decreasing the activity of osteoclasts cells [ 168].
Furthermore, the inhibition of APJ expression, PI3-K/Akt activation, or ERK activation, blocked effects of apelin on decreasing the activity of ALP.
Specifically, the authors used multiple complementary approaches to demonstrate that decreasing the activity of mTORC1, but not mTORC2, leads to lysosomal activation.
It is suggested that activation of adipocyte AMPK by NEFA, as well as decreasing the activity of hormone-sensitive lipase, could modulate adipose tissue dynamics by increasing FA esterification and, under certain circumstances, FA synthesis.
Notably, miR-210 facilitates tumor proliferation by activating cell cycle checkpoint and inhibits tumor cell death by decreasing the activity of caspase-8 or lowering the level of reactive oxygen species encouraging tumor cell immortality [ 93 95].
Studies have shown that hookworms reduce the risk of asthma by decreasing the activity of the human host's immune system.
Thus, pyruvate accumulation was achieved by decreasing the activity of the pyruvate dehydrogenase complex.
