Sentence examples for decreasing potency from inspiring English sources

Overall, both substructure analysis pipelines have proven to be able to highlight chemical moieties conferring or decreasing potency and selectivity in agreement with the literature.

Whereas the compounds containing the photoactivable groups maintained good inhibitory activity, the introduction of the bulky iodine atom was generally detrimental, decreasing potency significantly.

Truncated peptides bound to MHC class II molecules and induced TCR internalization and expression of interferon γ (IFN-γ) and tumor necrosis factor α (TNF-α) with decreasing potency.

Panic strikes as you draft equations in your head mapping the time of possible conception against closing hours at various pharmacies, while bearing in mind the decreasing potency of the pill.

Table 2 presents data for four peroxisome proliferators in order of decreasing potency for inducing mouse liver tumors.

(121) In a rank order of decreasing potency, FAAH inhibitory activity was reported for suprofen > ibuprofen > fenoprofen > naproxen > ketoprofen > diclofenac > sulindac.

The bacterial resistance is spreading throughout the world, revealing the steadily decreasing potencies of relevant antibiotics (Gould 2008) thus necessitating the discovery of novel compounds or modification of already existing antimicrobial stock.

While the replacement caused decreased potency, the activity can be largely improved by substituting the α,β-unsaturated ester with an aldehyde at the P1′ position.

Further experiments indicated that compound 17d displayed excellent activity to reduce mast cell degranulation, moderate anti-PAF activity and decreased potency on hERG compared to astermizole.

Two N-terminal members of the N-methyl library did not decrease potency and can be used as future drug leads.

The matrix metalloproteinase family has been a pharmaceutical target for most of the last three decades, but success has been hampered by unwanted side effects caused by lack of selectivity, poor oral bioavailability and decreased potency in vivo.