We compared the duration of the antibiotic course with: 1) the IDSA guidelines that recommend to use the decrease of fever and the need for surgical debridement and, 2) a theoretical duration if a PCT-based algorithm has been applied.
After the administration of the three ACT used in this study, it resulted in a rapid decrease of fever and parasite.
The outcomes of patients are shown in Table 3. Patients included in the MPDN group show a more favourable evolution of the pO2/FiO2 ratio, faster decrease of fever, as well as higher radiological improvement at seven days (P < 0.05).
Patients included in the MPDN group show a more favourable evolution of the pO2/FiO2 ratio and faster decrease of fever, as well as greater radiological improvement at seven days.
In this prospective, double-blinded, randomized study comparing methylprednisolone (MPDN) to a placebo combined with ceftriaxone plus levofloxacin in severe CAP, MPDN administration was associated with improved oxygenation, faster decrease of fever and radiological improvement.
In contrast, the community in the moderate transmission scenario (EIR ∼15) had some acquired clinical immunity, evidenced by the decreasing frequency of fever episodes with age.
9 Such confirmation is increasingly important in the context of declining malaria transmission, when a decreasing proportion of fever cases is likely to be caused by malaria.
Furthermore, professional oral care has been shown to reduce this number [ 21] and oral care decreased frequency of fever [ 22, 23] and mortality rate from pneumonia in the elderly [ 23 - 25.
No statistically significant difference was found regarding the period of decreasing fever, of the hospitalization's duration in patients with one, two or more organ dysfunctions with or without of identified etiologic agent.
Although there was significant decrease of the fever burden in the device group no difference could be found in the long-term, 6-month, patient follow-up.
This decrease was significant only for the single species product which also decreased the duration of fever.
