Several studies have been conducted on managing migraine headaches and developing effective medications for decreasing migraine-associated pain.
The present results, with no correlation between MSPA and number of headache days, do not directly support the concept of MSPA decreasing with migraine frequency, reaching minimal values in chronic migraine [7, 8].
Cognitive performance decreases during migraine, and cognitive dysfunction can be related to the duration and frequency of a migraine attack.
Moreover, there were significant trends of decreasing prevalence of migraine and non-migraine headache with the increasing number of alcohol units consumed [28, 31].
An interesting result was that EPC counts decreased as migraine progressed in time [20].
The activity level in the prefrontal cortex (PFC) and the rostral anterior cingulate cortex (rACC) increased in healthy control subjects from day one to day eight, whereas it decreased in migraine patients.
Cognitive performance decreases during migraine, especially in language, memory, executive functions, calculation and orientation, and cognitive dysfunctions can be related to the duration and the frequency of headache.
It was found that cognitive performance decreased during migraine attacks, especially in reading and processing speed, verbal memory and learning, supporting patients' subjective complaints.
Brachial artery diameter (mean 4.82 vs. 5.39 mm) and compliance (mean 0.30 vs. 0.37 mm2/kPa) were decreased in migraine patients compared with controls [56].
Migraine is associated with reduction in the number and function of endothelial progenitor cells, serving as a marker for dysfunction of the endothelium [12] and its counts decrease as migraine progresses in time [13].
