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Therefore, this decreasing eradication rate requires effective second-line treatment.
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The negative impact of clarithromycin resistance on the therapy success for H. pylori eradication is remarkable, decreasing the eradication rate by more than 20% [ 22].
This result might be related to the decreasing trend in eradication rate of standard triple therapy in Korea.
All patients previously submitted to only one treatment achieved successful eradication, but when 3 or more previous treatment regimens had failed, the eradication rate decreased to 57% (p = 0.004).
That is, the eradication rate of per protocol (PP) analysis decreased up to 75.9% in 2006 [ 9].
One study demonstrated that intravenous omeprazole can decrease the risk of peptic ulcer rebleeding and may even improve the Hp eradication rate of the subsequent triple therapy [ 107].
However, after adjusting for possible confounders (including age, sex, peptic ulcer history, ulcer bleeding history, H. pylori eradication rate, comorbidities, and medication), any-use of pioglitazone (OR = 0.93, P > 0.05) had no significant association with decreasing gastric cancer.
The compliance with the strategy has improved but the nasal eradication rate remains low.
E = eradication (presumed), and ER = eradication rate.
a Eradication rate defined as microbiologic eradication or presumed eradication.
The overall bacteriologic eradication rate was 91.9%.
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