Sentence examples for decreasing differentiation from inspiring English sources

When the number of colonizers is large and from multiple source populations, turnover will have a homogenizing effect decreasing differentiation (Slatkin 1977).

If populations are small and isolated from one another with increased habitat fragmentation, the genetic flow could be capable of influencing the genetic structure and decreasing differentiation among populations (Ellstrand and Elam 1993).

The PSA protein is strongly expressed, both in normal and neoplastic prostatic tissue; however, as evidenced by IHC staining, it is expressed less in cancer than in benign epithelium, and its expression decreases with the decreasing differentiation of PCa [ 76, 77].

For instance, resequencing the region around outliers may help to determine which polymorphism is actually under selection (i.e. the one showing the highest FST value, surrounded by decreasing differentiation on both sides; Box 3A) and provides data to estimate local recombination rates around the selected locus without needing a recombination map (Stumpf and McVean 2003).

In all, 44% of carcinomas showed marked loss or absence of expression and the fraction of tumours with reduced expression increased with decreasing differentiation and in tumours with metastases (62 vs 38% in tumours without metastases); 12 out of 13 metastatic lesions showed reduced expression.

DNMT3b is frequently overexpressed in tumor cells and its expression has been correlated with decreasing differentiation (Robertson et al. 1999).

In models of single colonic crypts composed of stem cells, differentiated cells and transit cells, increased proliferation, decreased differentiation or decreased apoptosis all lead to a net increase in cell number (67).

This effect resulted from a decreased differentiation and resorbing activity of osteoclasts and increased osteoclast apoptosis.

The down-regulation of both E-cadherin and β-catenin was correlated with decreased differentiation and increased tumour grade.

Pharmacological inhibition of PKCs or PKDs led to a markedly decreased differentiation of C2C12 cells.

This finding is important and supports observations of increased ROS, lipofuscin and decreased differentiation potential from aged mesenchymal stem cells [57].