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Decreasing cognitive function has been observed with increasing lead exposure in both children and adults (Mason et al. 2014; Brown and Margolis 2012).
As stated above, children with OSAHS often suffer from obviously decreasing cognitive function including lower learning abilities, decreased memory performance, and aprosexia, which may largely influence the QoL; thus children with OSAHS frequently have poor QoL.
The decline in completion rate with decreasing cognitive function was also found in the study by Gerritsen et al, which showed that 72% of people with MMSE scores of 5 12 completed the GDS, compared to 100% of people with MMSE scores 22 30 (Gerritsen et al., 2007).
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For example, Sclan and Reisberg [ 27], found that increasing functional disability assessed by FAST is significantly related to decreasing cognitive functioning (r = -0.79).
Inadequate cerebral blood flow has been found to be a likely cause or result of decreasing cognitive functions among those with cardiovascular diseases [ 32- 34], as well as correlated with age-related diseases such as Alzheimer's [ 35] and non-age related diseases such as Lyme disease [ 36].
Increase in severity of dementia corresponds with decreased cognitive function, memory loss, and, eventually, physical decline.
Tau protein aggregation leads to neuronal cell dysfunction and death, and studies show a strong association between tau deposits, decreased cognitive function, and neurodegenerative changes in AD.
Tracers are now being developed for evaluation of tau protein, which is associated with decreased cognitive function and neurodegenerative changes in AD, and is implicated in the pathogenesis of other neurodegenerative diseases.
The use of human plasma-derived butyrylcholinesterase (HuBuChE) to neutralize the toxic effects of nerve agents in vivo has been shown to both aid survival and protect against decreased cognitive function after nerve agent exposure.
The American Academy of Pediatrics took a very firm stand against pesticides recently, linking them to "pediatric cancers, decreased cognitive function, and behavioral problems".
APOC3 m482 was also associated with decreased cognitive function.
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