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The CD8-mediated response shows functional defects, with impaired production of interferon-γ, low perforin content, decreased capacity of expansion and lysis of target cells.
The increased fragility of sleep associated with aging probably reflects the decreased capacity of the sleeping brain to maintain steady states of vigilance.
Social exclusion worsens the body's ability to manage inflammations due to a decreased capacity of the anti-inflammatory hormone cortisol to do its job.
A consistent finding is the decreased capacity of cord blood-derived cells to produce bioactive IL-12p70 by monocytes and mDCs.
To further examine the apparent decreased capacity of the trkH mutant to survive in host blood, we incubated LVS and trkH mutant bacteria in murine blood ex vivo.
These abnormalities are associated with a decreased capacity of the cells for germ line colonization in chimeras obtained after blastocyst injection [30], [31].
However, a single residue mutation in 3Dpol (M296I) resulted in decreased capacity of the FMDV enzyme to use ribavirin triphosphate as a substrate in the place of GTP and ATP [19].
This growth difference resulted from a decreased capacity of Cd34−/− hair follicle bulge stem cells (which normally express CD34) to activate and switch to a proliferative state following TPA exposure [23].
Together, these results are consistent with decreased capacity of cytosolic copper binding and thus decreased protection against copper toxicity in diabetes.
The ensuing advantage is the preservation of the host endogenous normal flora and the limitation of the selective pressure, which results in a decreased capacity of drug resistance.
On the other hand the lack of increased sc-kit levels in patients with severe asthma could reflect decreased capacity of their serum to neutralize activity of SCF.
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