Stromal cells over-expressing NICD1 reduced M-CSF production and enhanced RANKL and OPG production, resulting in the decreased capability of these cells to support osteoclastogeneis (Yamada et al., 2003).
Parthenogenetically activated oocytes of importin α7ΔIBB/ΔIBB females with successful pronuclear formation showed a markedly decreased capability to develop into two-cell embryos (Tab. 2).
The Bcl-x-null cells exhibited a decreased capability to invade under conditions mimicking hypoxia; in contrast, when the same cells were assayed in normal conditions, their invasiveness was comparable to Bcl-x proficient cancer cells.
This implies decreased capability of the 5'-end promoters in initiating transcription after treatment with alcohol.
We have screened a transposon mutant library of R. equi for mutants with decreased capability to prevent phagolysosome formation.
Unmet Needs theory (2) claims that challenging behavior is caused by the decreased capability of clients with dementia to explain their needs.
Tunicamycin apparently decreased capability to form experimental metastases but also diminished tumourigenicity on subcutaneous inoculation, although it did not affect tumour cell viability in vitro.
One of the important biochemical differences between normal and cancer cells is a decreased capability of cancer cells to buffer high ROS levels.
Therefore, it is likely that the individual with the variants of C421A A allele and/or G34A A allele may have decreased capability to exclude the carcinogens and thereby becomes susceptible to carcinogenesis.
With this in mind, we hypothesize that the protective effect of a P1[B] deletion genotype of the 12p13.31 CNV may be due to a decreased capability of individuals with this variant to express SLC2A3.
Importantly, our observation of a decreased capability of the cKO mice during the acquisition phase in the radial arm maze, and the observations we make in the seizure-prone slice preparation could also be due to a loss of glutamatergic signalling, by the targeting of " Vglut2- only" cells and the glutamatergic, instead of the dopaminergic, component of the glutamate/DA cophenotypic cells.
