Interestingly, the mutant GLI3 proteins had significantly decreased capabilities to induce the luciferase signal, suggesting that indeed the misregulated localization of mutant GLI3 leads to a decrease in its transcriptional activity (Fig. 5a).
Considering the fact that microRNAs bind to complementary sites of 3'-UTR to induce RNA degradation, the positive MI values can be translated to the decreased capabilities to trigger RNA degradation in androgen-independent prostate tumors.
Considering the fact that miRNAs trigger sequence-specific RNA degradation by binding in the 3'-UTR, a positive Xm values are indicative of decreased capabilities of a miRNA to trigger RNA degradation in the presence of alcohol.
Stromal cells over-expressing NICD1 reduced M-CSF production and enhanced RANKL and OPG production, resulting in the decreased capability of these cells to support osteoclastogeneis (Yamada et al., 2003).
Parthenogenetically activated oocytes of importin α7ΔIBB/ΔIBB females with successful pronuclear formation showed a markedly decreased capability to develop into two-cell embryos (Tab. 2).
The Bcl-x-null cells exhibited a decreased capability to invade under conditions mimicking hypoxia; in contrast, when the same cells were assayed in normal conditions, their invasiveness was comparable to Bcl-x proficient cancer cells.
This implies decreased capability of the 5'-end promoters in initiating transcription after treatment with alcohol.
We have screened a transposon mutant library of R. equi for mutants with decreased capability to prevent phagolysosome formation.
Unmet Needs theory (2) claims that challenging behavior is caused by the decreased capability of clients with dementia to explain their needs.
Tunicamycin apparently decreased capability to form experimental metastases but also diminished tumourigenicity on subcutaneous inoculation, although it did not affect tumour cell viability in vitro.
One of the important biochemical differences between normal and cancer cells is a decreased capability of cancer cells to buffer high ROS levels.
