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Thus, once-daily dosing may increase the therapeutic-toxicity ratio by increasing efficacy and decreasing adverse effects [ 57].
In our institution, these efforts have been made with the goal of raising the local control rate and decreasing adverse effects after SBRT.
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The in vivo therapeutic studies in MCF-7 human breast tumor-bearing nude mice show that DOX-CLNPs effectively inhibit tumor growth, improve survival rate, and significantly decrease adverse effects as compared to DOX-LPs.
These results taken together could provide impetus for rational design and optimization of more selective and high affinity leads with a potential to have decreased adverse effects.
It was proposed that a targeted delivery of IL-18 by generation of IL-18-EGF fusion protein might decrease adverse effects and result in enhancing cytotoxic and antitumor activities.
Saliva samples are notoriously variable in terms of composition and viscosity, even within the same donor sample collected over a short period of time, and it is probable that an on-strip dilution of the sample would decrease adverse effects arising from sample variability and viscosity, however this would require controlled sample dilution.
These data suggest that selective MKK7 blockade could suppress arthritis and potentially decrease adverse effects by permitting non-pathogenic MKK4-mediated JNK activation.
In our institution, the procedures described here have been explored in order to raise the local control rate and decrease adverse effects after SBRT.
TENS improved incontinence symptoms, enhanced the quality of life, and decreased adverse effects; hence, it is recommended in treating poststroke UI.
In conclusion, TENS improved urinary symptoms and quality of life and decreased adverse effects in this group of patients with poststroke UI.
Greater clinician and pharmacist awareness of all the different prescribed and self-directed regimens patients are using may lead to more proactive interventions to decrease adverse effects of supplement use.
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