Decreasing abundance of L-proline was identified as a crucial biomarker for indexing higher water temperature and a potential modulator to reduce the high death.
Microarray analyses showed decreased abundance of transcripts for proteins that have a major part in transendothelial migration of leukocytes, including annexin 2, myosin 9 - a non-muscle motor protein, and integrin beta; CD9 and CD63 expressed on leukocyte membranes interact with integrins and proteins of extracellular matrix.
NMD was first identified in the late 1970's in thalassemic carriers of nonsense globin mutations as the cause for decreased abundance of affected mRNA transcripts, rather than production of truncated proteins [ 54].
To find out if the predicted instability of mutant Gigaxonins could account for the decreased abundance of Gigaxonin in patients, we determined the half-lives of wild type and mutated Gigaxonin.
The RR value is a surrogate for an increased or decreased abundance of miRNA targets relative to total mRNAs.
Altogether, increased abundance was observed for 1958 individual genes at least once between two consecutive time points, and decreased abundance was observed for 1960 genes.
In addition, one of the profiles representing proteins with higher abundance (49), was only significant for SW93-1015 and Sarpo Mira, and represented a large number of proteins for these clones, 203 and 91 proteins respectively.> -wrap-foot> Proteins with decreased abundance in the secretome for the compatible clone Desiree, but not for the two incompatible clones Sarpo Mira and SW93-1015.
This likely explains why one MF (174.0636) selected during the discovery phase for decreased abundance between D0 and M1 was subsequently shown to increase in abundance after the start of treatment when LC-MS data were analyzed for down selection and qualification.
The two most highly represented COG categories (other than unknown function) for proteins with decreased abundance were associated with amino acid transport and metabolism (14 proteins) and energy production and conversion (17 proteins).
GO terms for genes with decreased abundance specifically during acute infection were proteolysis, protein metabolic process, and anatomical structure, while GO terms specific to chronic infection were cell-cell communication and primary metabolic function.
