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Here, the generalized model analysis showed that the area of parameter space most likely realized in vivo is close to Hopf and saddle-node bifurcations, which enhances responsiveness, but decreases stability against perturbations.
In general, it can be seen how bulky aromatic residues (W,Y,F,H) tend to decrease stability ( = increase energy) at every position, and in four positions (21,68,231,232) any residue besides glycine or alanine decreases stability dramatically.
Noise also decreases stability and robustness of steady states.
Peroxidases use hydrogen peroxide as an oxidant, a process which decreases stability of forming epoxides for their further enzymatic transformations.
The effect of cavity formation in a protein has been experimentally measured; it decreases stability ~3.3 kcal/mol [ 38].
Secondly, the fact that strong trade-off effects would cause residue co-evolution (for instance, if a mutation improves function while it strongly decreases stability it will occur during evolution coupled with mutations that strongly increase stability).
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In summer, lake cooling serves to stabilize the air mass, but winter heating tends to decrease stability.
Morsi's year in office had seen decreasing stability and a stagnant economy.
The Financial Services Roundtable, which represents US banks, argued that the plans would "restrict lending, increase risk, decrease stability in the system, and limit our ability to help create jobs".
That can decrease stability in fast turns.
In some cases, users have been reporting that the frame rate has actually even dropped, or that the new drivers have decreased stability.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com