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The expression of target genes in Escherichia coli is usually controlled by the high-strength inducible promoter with the result that the abnormally high transcription of these genes creates excessive metabolic load on the host, which decreases product formation.
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Without a functioning TE2, erroneous acyl chains on a Pks module clog the machinery, decreasing product production by up to 90% [38].
As these inhibitors can affect microbial growth, decrease product yield and productivity; prolong lag phase of microbial growth, and reduce cellular viability [39],[40], several evolutionary or metabolic engineering strategies have been employed to develop strains able to tolerate them.
Oxygen transfer problems associated with fluid dynamics and inefficient mixing efficiencies result in oxygen gradients, which lead to reduced performance of the bioprocess, decreased product yields, and increased production costs.
Faced with decreasing product prices and increasing production costs during the last two decades family farmers in south Uruguay tried to maintain their income by intensifying their farms, growing larger areas of fewer crops and increasing the use of irrigation and agrochemicals.
κ-Carrageenan decreased product viscosity.
For standardization bodies, it would cause a decreased product quality: ambiguous terminology will lead to ambiguous standards.
Ahmed Alkhatib, founder and CEO, MarkaVIP says the company pursued the funding to "focus on decreasing product delivery lead times and improve quality across the board".
However, during ageing under high humidity (95%) and temperature (70 °C), hydrolysis can degrade PUF, decreasing product quality.
In order to decrease product loss, an attempt has been made to optimize the settings of the LRC grinding process.
This leads to an increased adduct (PMT) adsorption and decreased product (PMBA) adsorption in the order V2O5
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