The overall goal of the active treatments was to improve functioning (decrease of functional limitations).
This is explainable by a greater decrease of functional residual capacity (FRC) as well as other lung function parameters due to relevant atelectasis formation.
These effects may in part contribute to the decrease of functional loads in the anterior mouth by a volume-reduced tongue.
These results lead to the proposal that effective blood substitutes must be designed to prevent microvascular collapse, manifested in the decrease of functional capillary density.
Analysis of functional diversity indices based on all measured traits showed a decrease of functional divergence due to mowing (indicating convergence of traits) and no response of functional richness, evenness and functional dispersion.
Interestingly, the relative decrease of functional alpha-4 integrin was less pronounced in Tregs in comparison to Foxp3 negative T cells suggesting that Natalizumab may preferentially block the migration of T effector cells and thus favour the extravasation of Tregs.
By comparison, for the default mode network, there was also decreased of functional connectivity between the posterior cingulate and medial frontal cortex in the sad relative to neutral recall condition (x, y, z = 6, 54, 12; z = 2.93; 23 voxels).
In that perspective, ruling out the existence of a method-induced, hypothesis-unspecific decrease of functional connectivity should be a matter of concern, which could be solved, e.g., by finding a specific, hypothesis-driven increase of functional connectivity within the same regions.
Although our investigation showed that our main conclusion (a condition-dependent decrease of functional connectivity in the DMN) holds across all ROI selection methods examined, one should bear in mind that all ROI selection methods considered here were based on resting-state data only.
We agree that measurement of mEPSCs would confirm a decrease of functional spines in the hippocampus.
