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A more widespread adoption has been limited because of its rapid degradation at room temperature that decreases its functionality.
Therefore, loss of cardiomyocytes causes permanent damage of heart that progressively decreases its functionality and could eventually lead to heart failure and death.
A change to a protein's sequence that decreases its functionality by a small fraction will, by assumption, have the same effect on fitness as the loss of the same fraction of the protein.
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While structured programming is known for years, it limits the ability to handle a large code without decreasing its functionality and manageability [ 29].
In this issue of EBioMedicine, Kandioler et al. analyzed TP53 mutations which produce a partial functionality of the protein (decreasing its transcriptional activity to less than 75%) in stage III colon cancer patients (Kandioler et al., in press).
As the descriptor calculation software become more complex and their shared functionality decreases, it will be far more likely to see divergence into more and more niche ontologies rather than convergence into a single across-the-board ontology.
At times when I feel I may be inconveniencing others – in the supermarket check-out, at the self-service ticket machine – my stress level increases, which decreases my functionality and thus proves a self-fulfilling prophecy.
This might be because cast immobilization decreases functionality due to muscle wasting, although it contrasts with the findings of Lamb and colleagues [7], who advocated the use of a plaster cast due the resulting improved functional outcomes.
It's quite simple in its functionality.
without affecting its functionality.
Its functionality can be extended via plugins.
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