Inhibitory serine phosphorylation of IRS-1 decreased in the context of hypoinsulinemia following STZ treatment.
Similarly, both glycogen and CD caused a significant (P < 0.01) signal decrease in the context of non-phosphorylated AMPK and a smaller decrease in the context of phosphorylated AMPK, indicating that carbohydrate binding modulates the CBM-KD interaction also in the context of the AMPK complex.
We speculate that the knowledge obtained from these experiments also supports the need for strict blood pressure control in other forms of obesity and insulin resistant states where levels of PPARγ may be decreased in the context of the metabolic syndrome.
HCA decreases hyperlactatemia in the context of global hypoxemia as well as during normoxia [ 15, 70, 97].
As mutations in the human SETX gene cause multiple neurodegenerative disorders29,30,31,32, we used quantitative IHC and RT-PCR to confirm decreased SETX in the context of normal transcription (Supplementary Fig. 3).
Specifically, downregulation of this miRNA seems to decrease proliferation in the context of hepatic stellate cell activation, an early event in liver fibrosis [81].
Greece is currently going through the most significant economic crisis in its modern history, and public health budgets are decreasing rapidly in the context of austerity measures that aim to reduce public spending.
In animal models of uncontrolled infection, PD-1 expression decreased on epitope-specific CD8+ T cells as they decreased in frequency in the context of emerging viral escape mutations [16], [34], [36].
An increase of %SFA, without significant changes in absolute saturated fat intake, over 12 months was associated with a statistically significant decrease in triglycerides in the context of a weight-loss study in which participants simultaneously decreased carbohydrate intake.
The fiscal policy of both eras, the booming 1980s and the booming 1990s, was the same: decreasing tax rates in the context of government spending made unnecessary by real-economy growth.
