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Predator-induced defensive morphologies in Daphnia pulex are associated with decreases in longevity and clutch size, both of which affect population growth rate [35].
It is well known that mating can lead to large decreases in longevity within nematodes (e.g., [ 37]).
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Strong RNAi knockdown of EcR leads to a decrease in longevity [ 76].
A mutation at the loci of each of those genes causes a decrease in longevity except for Tor, whose inhibition increase longevity [ 63].
In that case, the population is less likely to decrease, so it is better to reproduce earlier, despite any resulting decrease in longevity.
Thus, decrease in longevity can be associated with accumulation of aggregation-prone proteins, whereas lower hydrophobicity is linked to different type of deposits and significantly reduced toxicity.
In the most recent study, feeding on NaBu during only the initial stages (days 1-21) or throughout adulthood led to a decrease in longevity, while feeding only after 21 days led to extended longevity [ 49].
Similar to these and other studies, within each accession, there were increases in p50 the later the seeds were harvested, with, in some instances, a decrease in longevity at the final harvest (indicative of on-plant ageing; Fig. 4).
Moreover, an early-life administration of GH to long-living df/df mice leads to reduced insulin sensitivity (Masternak et al., 2010) and a decrease in longevity (Panici et al., 2010).
A 0.01% solution of casein hydrolysate, which produced a half maximum decrease in longevity, corresponded to a 1 mM solution of amino acids (considering that the average molecular weight of an amino acid is 100 Da).
At these sites, increases in Tmin occurred only within the past 20 25 years and decreases in snowpack longevity were more subtle.
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