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While increases in gallbladder volume and decreases in gallbladder function did not appear to be dose- or schedule-dependent, gallbladder toxicity occurred only in Arm A (motesanib 125 mg QD).
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In this randomized phase 1b study designed to assess gallbladder-related toxicity among patients receiving three motesanib dose schedules, increased gallbladder volume, decreased gallbladder function, and other gallbladder changes, including development of gallstones and sludge, were common.
In each arm, mean changes from last on-treatment to last available off-treatment measurement indicated a decrease in gallbladder volume (Table 2).
After the treatment, the fistula should heal, resulting in the possibility that gallbladder function could be preserved.
Men, particularly uneducated men, also experienced greater decreases in cognitive function compared to women.
Gallbladder function is routinely assessed using ultrasonographic (USG) examinations.
Leptin administration to these mice causes weight loss and restores gallbladder function.
Motesanib treatment also affected gallbladder function.
Hence, drugs used to treat this condition should not adversely affect gallbladder function.
If gallbladder function is compromised and the gallbladder doesn't empty as quickly as it should, a gallbladder attack may occur.
Regardless of the cause, the result is the same: an abrupt decrease in kidney function.
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