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Our genetic studies support various biochemical and tissue culture models whereby decreases in capulet function lead to increased actin in small aggregates, while over-expressed Cofilin in a capulet mutant background leads to larger accumulation in actin rod-like structures.
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Perturbations in Capulet function not only affect actin dynamics, but also microtubule-based processes.
The results showed that men in both treatment groups experienced significant decreases in sexual function.
Men, particularly uneducated men, also experienced greater decreases in cognitive function compared to women.
Our results suggest mechanisms by which loss of capulet function interacts with impaired Kinesin function to produce similar actin rods.
When Capulet function is reduced, endogenous Cofilin may have less F-actin depolymerizing activity leading to actin filament accumulation.
We wondered what genes, other than actin-binding proteins, might be relevant to capulet function, which could also explain the mitochondrial phenotype.
Dramatic decreases in brain reward function during nicotine withdrawal.
It is further hypothesised that the relative decrease in muscle power output will exceed the relative decrease in cognitive function.
Panda, A. et al. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.
Regardless of the cause, the result is the same: an abrupt decrease in kidney function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com