Widespread pain may not be a good indicator of multiple pain comorbidities since it tends to be more severe, longer lasting, and accompanied by decreased functionality and poorer general health [12].
The degree to which they can function is impressive given that such a change shape from the natural form should lead to decreased functionality.
The coagulation factors are produced, but have decreased functionality due to undercarboxylation; they are collectively referred to as PIVKAs (proteins induced [by] vitamin K absence/antagonism), and individual coagulation factors as PIVKA-number (e.g.PIVKA-II).
The decreased functionality and anomalous behavior of the left fronto-cingulate-parietal-basal ganglia neurocognitive network observed in schizophrenia in our study is consistent with prior studies that have examined working memory-related BOLD activation [13], [21], [22], [36].
Although our old dogs were clinically healthy, our observations indicate that the aged colon appears to have an increased risk of inflammation and a decreased functionality of cellular defensive mechanisms.
In many tumor types, including Ewing sarcoma, host immune cells have decreased functionality when compared with healthy donor cells [ 13, 44, 45].
The pathologies of CCD-afflicted humans are a result of the decreased functionality of the DNA binding region in the regulatory locus Runx2 [ 19, 20].
For example, the HPO-term Gallbladder dysfunction (HP 0005609) has as alt_id the ZP-term abnormal ly) decreased functionality gall bladder (ZP 0004170).
Depending on the extent of this decreased functionality, CCD humans show a mix of phenotypes, often (but not always) including features exhibited in afrotherians.
PUFAs including ARA, EPA, and DHA may play a vital role in the regulation of membrane fluidity in this organism, thereby compensating for the decreased functionality of the biomembranes under cold stress conditions.
