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If the product is not fit-for-purpose, further time and expense are incurred to effect remedy which, if not possible, decreases benefit.
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Time-series analysis of the forces on the tank and the pressures inside it during a typical stop showed a decreasing benefit with more than three baffies.
A decreased benefit from hormone therapy was suggested in the HER2+ER+ subset of SBC 21, 23.
High expression of EGFR appears to be associated with decreased benefit from adjuvant concurrent trastuzumab.
In general, there appeared to be a trend of decreasing benefit as the years of observation increased.
Patients with these conditions were considered to have decreased benefit and/or increased risk from intensive treatment (7).
In the first scenario we are weighing increased benefit against increased risk, while in the latter we are weighing decreased benefit against decreased risk.
In line with these findings, Akt-positive patients showed decreased benefit from radiotherapy as concerns the locoregional control in the present study.
A high HOXB13 expression was associated with decreased benefit from tamoxifen, which indicates that HOXB13 protein level may be used as a predictive marker for tamoxifen treatment.
In a previous study of 5 years versus 2 years of tamoxifen treatment, we found a decreased benefit from prolonged treatment in relation to erbB2 overexpression [ 29].
In addition, high cytoplasmic 4EBP1 protein levels predicted a poor prognosis and a decreased benefit from tamoxifen in a large randomised cohort.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com